Imatinib inhibits various types of activating mutant kit found in gastrointestinal stromal tumors.

@article{Chen2003ImatinibIV,
  title={Imatinib inhibits various types of activating mutant kit found in gastrointestinal stromal tumors.},
  author={Hui Chen and Koji Isozaki and Kazuo Kinoshita and Akiko Ohashi and Yasuhisa Shinomura and Yuji Matsuzawa and Yukihiko Kitamura and Seiichi Hirota},
  journal={International journal of cancer},
  year={2003},
  volume={105 1},
  pages={
          130-5
        }
}
Mutations of proto-oncogene c-KIT in gastrointestinal stromal tumors (GISTs) are considered to cause a constitutive activation of KIT responsible for their oncogenesis. Imatinib has therapeutic potential for GISTs because of its inhibitory effect on KIT kinase activity. To investigate the effect of Imatinib on various c-KIT mutations found in GISTs, we examined kinase activity of KIT, cell proliferation and tumorigenicity of transfectants with various c-KIT mutations. Murine lymphoid Ba/F3… CONTINUE READING
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