Imatinib increases oxygen delivery in extracellular matrix-rich but not in matrix-poor experimental carcinoma

@inproceedings{Burmakin2017ImatinibIO,
  title={Imatinib increases oxygen delivery in extracellular matrix-rich but not in matrix-poor experimental carcinoma},
  author={Mikhail Burmakin and Tijs van Wieringen and P Olof Olsson and Linda E B Stuhr and Aive {\AA}hgren and Carl-Henrik Heldin and Rolf K. Reed and Kristofer Rubin and Carina Hellberg},
  booktitle={Journal of Translational Medicine},
  year={2017}
}
BackgroundImatinib causes increased turnover of stromal collagen, reduces collagen fibril diameter, enhances extracellular fluid turnover and lowers interstitial fluid pressure (IFP) in the human colonic carcinoma KAT-4/HT-29 (KAT-4) xenograft model.MethodsWe compared the effects of imatinib on oxygen levels, vascular morphology and IFP in three experimental tumor models differing in their content of a collagenous extracellular matrix.ResultsNeither the KAT4 and CT-26 colonic carcinoma models… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES