Imatinib increases oxygen delivery in extracellular matrix-rich but not in matrix-poor experimental carcinoma

Abstract

Imatinib causes increased turnover of stromal collagen, reduces collagen fibril diameter, enhances extracellular fluid turnover and lowers interstitial fluid pressure (IFP) in the human colonic carcinoma KAT-4/HT-29 (KAT-4) xenograft model. We compared the effects of imatinib on oxygen levels, vascular morphology and IFP in three experimental tumor models… (More)
DOI: 10.1186/s12967-017-1142-7

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Cite this paper

@inproceedings{Burmakin2017ImatinibIO, title={Imatinib increases oxygen delivery in extracellular matrix-rich but not in matrix-poor experimental carcinoma}, author={Mikhail Burmakin and Tijs van Wieringen and P Olof Olsson and Linda Elin Birkhaug Stuhr and Aive {\AA}hgren and Carl-Henrik Heldin and Rolf K. Reed and Kristofer Rubin and Carina Hellberg}, booktitle={Journal of Translational Medicine}, year={2017} }