Imatinib enhances human melanoma cell susceptibility to TRAIL-induced cell death: relationship to Bcl-2 family and caspase activation

@article{Hama2006ImatinibEH,
  title={Imatinib enhances human melanoma cell susceptibility to TRAIL-induced cell death: relationship to Bcl-2 family and caspase activation},
  author={Ahmed Hama{\"i} and Catherine Richon and Franck Meslin and Florence Faure and Audrey Kauffmann and Yann L{\'e}cluse and Abdelali Jalil and Lionel Larue and Marie Avril and Salem Chouaib and Maryam Mehrpour},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={7618-7634}
}
In order to define genetic determinants of primary and metastatic melanoma cell susceptibility to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), we have applied oligonucleotide microarrays to TRAIL-sensitive primary T1 cells and TRAIL-resistant metastatic G1 cells treated or not with TRAIL. T1 and G1 cells are isogenic melanoma cell subclones. We examined 22 000 spots, 4.2% of which displayed differential expression in G1 and T1 cells. Cell susceptibility to TRAIL-mediated… CONTINUE READING