Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance.

@article{Nakasone2012ImagingTI,
  title={Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance.},
  author={Elizabeth S. Nakasone and Hanne Arenberg Askautrud and Tim Kees and Jae-Hyun Park and Vicki Plaks and Andrew J Ewald and Miriam R. Fein and Morten Gr\onbech Rasch and Ying-Xim Tan and Jing Qiu and Juwon Park and Pranay Sinha and Mina J. Bissell and Eirik Frengen and Zena Werb and Mikala Egeblad},
  journal={Cancer cell},
  year={2012},
  volume={21 4},
  pages={488-503}
}
Little is known about the dynamics of cancer cell death in response to therapy in the tumor microenvironment. Intravital microscopy of chemotherapy-treated mouse mammary carcinomas allowed us to follow drug distribution, cell death, and tumor-stroma interactions. We observed associations between vascular leakage and response to doxorubicin, including… CONTINUE READING