Imaging the quantal substructure of single IP3R channel activity during Ca2+ puffs in intact mammalian cells.

@article{Smith2009ImagingTQ,
  title={Imaging the quantal substructure of single IP3R channel activity during Ca2+ puffs in intact mammalian cells.},
  author={Ian F Smith and Ian Parker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 15},
  pages={6404-9}
}
The spatiotemporal patterning of Ca(2+) signals regulates numerous cellular functions, and is determined by the functional properties and spatial clustering of inositol trisphosphate receptor (IP(3)R) Ca(2+) release channels in the endoplasmic reticulum membrane. However, studies at the single-channel level have been hampered because IP(3)Rs are inaccessible to patch-clamp recording in intact cells, and because excised organelle and bilayer reconstitution systems disrupt the Ca(2+)-induced Ca(2… CONTINUE READING
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