Imaging the permeability pore transition in single mitochondria.

  title={Imaging the permeability pore transition in single mitochondria.},
  author={J{\"o}rg H{\"u}ser and Christine E. Rechenmacher and Lothar A Blatter},
  journal={Biophysical journal},
  volume={74 4},
In mitochondria the opening of a large proteinaceous pore, the "mitochondrial permeability transition pore" (MTP), is known to occur under conditions of oxidative stress and matrix calcium overload. MTP opening and the resulting cellular energy deprivation have been implicated in processes such as hypoxic cell damage, apoptosis, and neuronal excitotoxicity. Membrane potential (delta psi(m)) in single isolated heart mitochondria was measured by confocal microscopy with a voltage-sensitive… CONTINUE READING
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