Imaging the glycome.

@article{Laughlin2009ImagingTG,
  title={Imaging the glycome.},
  author={Scott T Laughlin and Carolyn R Bertozzi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 1},
  pages={12-7}
}
Molecular imaging enables visualization of specific molecules in vivo and without substantial perturbation to the target molecule's environment. Glycans are appealing targets for molecular imaging but are inaccessible with conventional approaches. Classic methods for monitoring glycans rely on molecular recognition with probe-bearing lectins or antibodies, but these techniques are not well suited to in vivo imaging. In an emerging strategy, glycans are imaged by metabolic labeling with chemical… CONTINUE READING

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