Imaging the genetics of brain structure and function
- Psychology, BiologyBiological Psychology
Dorsolateral Prefrontal Cortex Magnetic Resonance Imaging Measurements and Cognitive Performance in Autism
- PsychologyJournal of child neurology
Findings from this study suggest that executive function deficits observed in autism are related to functional but not anatomical abnormalities of the frontal lobe, and suggests that executive dysfunction is not the result of focal brain alterations but, rather, is the results of a distributed neural network dysfunction.
[Neuropsychological models of autism spectrum disorders - behavioral evidence and functional imaging].
- Psychology, BiologyZeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie
A better understanding of the complexities of ASD in future research demands the integration of clinical, neuropsychological, functional imaging, and molecular genetics evidence.
Phenotypic regional fMRI activation patterns during memory encoding in MCI and AD
- Biology, Psychology
Alex consistencies broadly support the presence of frontal compensatory activity, MTL activity alteration, and posterior midline “default mode” hyperactivation during episodic memory encoding attempts in the diseased or prospective pre-disease condition.
Neuroimaging of Attention
- Psychology, Biology
Neuroimaging has become a primary method for cognitive neuroscience research over the past 2 decades, providing a powerful tool for studying brain structure and function, and has evolved to the point that many universities now have research-dedicated MR scanners, in many cases located in psychology or neuroscience departments.
The Neural Correlates of Working Memory in Children and Adolescents with ASD and the Effects of Cognitive Load
- Psychology, Biology
Results suggest that children with ASD rely mainly on posterior brain regions associated with lower-level visual processing, whereas controls showed activity in frontal lobes related to the classic WM network.
The neural correlates of visuo-spatial working memory in children with autism spectrum disorder: effects of cognitive load
- Psychology, MedicineJournal of Neurodevelopmental Disorders
The data suggest that children with ASD rely mainly on posterior brain regions associated with visual and lower level processing, whereas controls showed activity in frontal lobes related to the classic WM network.
EEG anomalies in adult ADHD subjects performing a working memory task
- Psychology, BiologyNeuroscience
Autism Spectrum Disorder: Does Neuroimaging Support the DSM-5 Proposal for a Symptom Dyad? A Systematic Review of Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging Studies
- PsychologyJournal of autism and developmental disorders
A systematic review of 208 studies comprising functional magnetic resonance imaging and diffusion tensor imaging data in patients with ‘autism spectrum disorder’ was conducted, and partially supports the DSM-5 proposal of a social communication and behavioral symptom dyad.
Neurodevelopment and executive function in autism
- Psychology, BiologyDevelopment and Psychopathology
Evidence from studies probing response inhibition and working memory indicate impairments in these core components of executive function, as well as compensatory mechanisms that permit normative function in autism.
SHOWING 1-10 OF 204 REFERENCES
Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia.
- Psychology, MedicineThe American journal of psychiatry
OBJECTIVE The identification of neurobiological intermediate phenotypes may hasten the search for susceptibility genes in complex psychiatric disorders such as schizophrenia. Earlier family studies…
Assessing the molecular genetics of attention networks
- Biology, PsychologyBMC Neuroscience
The ANT is validated as an endophenotypic assay suitable for assessing how genes influence certain anatomical networks that may be disrupted in various psychiatric disorders and suggests that genetic variation may underlie inter-subject variation in the efficiency of executive attention.
Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited.
- Psychology, BiologyCerebral cortex
The data suggest that under certain conditions the physiological ramifications of dorsal PFC neuronal pathology in schizophrenia includes exaggerated and inefficient cortical activity, especially of lateral PFC.
Neurocognitive deficit in schizophrenia: a quantitative review of the evidence.
- Psychology, MedicineNeuropsychology
The results indicate that schizophrenia is characterized by a broadly based cognitive impairment, with varying degrees of deficit in all ability domains measured by standard clinical tests.
The effect of working memory performance on functional MRI in schizophrenia
- Psychology, MedicineSchizophrenia Research
Mapping the genetic variation of executive attention onto brain activity
- Biology, PsychologyProceedings of the National Academy of Sciences of the United States of America
Genotyping 16 subjects for the DRD4 and MAOA genes found a polymorphism in which persons with the allele associated with better behavioral performance showed significantly more activation in the anterior cingulate while performing the Attention Network Test (ANT).
The Cognitive Genetics of Attention Deficit Hyperactivity Disorder (ADHD): Sustained attention as a Candidate Phenotype
- Psychology, BiologyCortex
Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance
- Psychology, BiologyPsychiatry Research: Neuroimaging
Functional neuroanatomy of working memory in adults with attention-deficit/hyperactivity disorder
- Psychology, MedicineBiological Psychiatry
Timing, Space and ADHD: The Dopamine Theory Revisited
- Psychology, BiologyThe Australian and New Zealand journal of psychiatry
The dopamine theory of attention deficit hyperactivity disorder (ADHD) in terms of advances made over the last decade is reviewed, and a potential role for α2 noradrenergic agonists such as guanfacine is suggested.