Imaging the genetics of executive function

  title={Imaging the genetics of executive function},
  author={Ciara M. Greene and Wouter Braet and Katherine A. Johnson and Mark A. Bellgrove},
  journal={Biological Psychology},
Dorsolateral Prefrontal Cortex Magnetic Resonance Imaging Measurements and Cognitive Performance in Autism
Findings from this study suggest that executive function deficits observed in autism are related to functional but not anatomical abnormalities of the frontal lobe, and suggests that executive dysfunction is not the result of focal brain alterations but, rather, is the results of a distributed neural network dysfunction.
[Neuropsychological models of autism spectrum disorders - behavioral evidence and functional imaging].
  • I. Dziobek, S. Bölte
  • Psychology, Biology
    Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie
  • 2011
A better understanding of the complexities of ASD in future research demands the integration of clinical, neuropsychological, functional imaging, and molecular genetics evidence.
Phenotypic regional fMRI activation patterns during memory encoding in MCI and AD
Alex consistencies broadly support the presence of frontal compensatory activity, MTL activity alteration, and posterior midline “default mode” hyperactivation during episodic memory encoding attempts in the diseased or prospective pre-disease condition.
Neuroimaging of Attention
Neuroimaging has become a primary method for cognitive neuroscience research over the past 2 decades, providing a powerful tool for studying brain structure and function, and has evolved to the point that many universities now have research-dedicated MR scanners, in many cases located in psychology or neuroscience departments.
The Neural Correlates of Working Memory in Children and Adolescents with ASD and the Effects of Cognitive Load
Results suggest that children with ASD rely mainly on posterior brain regions associated with lower-level visual processing, whereas controls showed activity in frontal lobes related to the classic WM network.
The neural correlates of visuo-spatial working memory in children with autism spectrum disorder: effects of cognitive load
The data suggest that children with ASD rely mainly on posterior brain regions associated with visual and lower level processing, whereas controls showed activity in frontal lobes related to the classic WM network.
EEG anomalies in adult ADHD subjects performing a working memory task
Autism Spectrum Disorder: Does Neuroimaging Support the DSM-5 Proposal for a Symptom Dyad? A Systematic Review of Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging Studies
A systematic review of 208 studies comprising functional magnetic resonance imaging and diffusion tensor imaging data in patients with ‘autism spectrum disorder’ was conducted, and partially supports the DSM-5 proposal of a social communication and behavioral symptom dyad.
Neurodevelopment and executive function in autism
Evidence from studies probing response inhibition and working memory indicate impairments in these core components of executive function, as well as compensatory mechanisms that permit normative function in autism.


Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia.
OBJECTIVE The identification of neurobiological intermediate phenotypes may hasten the search for susceptibility genes in complex psychiatric disorders such as schizophrenia. Earlier family studies
Assessing the molecular genetics of attention networks
The ANT is validated as an endophenotypic assay suitable for assessing how genes influence certain anatomical networks that may be disrupted in various psychiatric disorders and suggests that genetic variation may underlie inter-subject variation in the efficiency of executive attention.
Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited.
The data suggest that under certain conditions the physiological ramifications of dorsal PFC neuronal pathology in schizophrenia includes exaggerated and inefficient cortical activity, especially of lateral PFC.
Neurocognitive deficit in schizophrenia: a quantitative review of the evidence.
The results indicate that schizophrenia is characterized by a broadly based cognitive impairment, with varying degrees of deficit in all ability domains measured by standard clinical tests.
Mapping the genetic variation of executive attention onto brain activity
Genotyping 16 subjects for the DRD4 and MAOA genes found a polymorphism in which persons with the allele associated with better behavioral performance showed significantly more activation in the anterior cingulate while performing the Attention Network Test (ANT).
Timing, Space and ADHD: The Dopamine Theory Revisited
  • F. Levy, J. Swanson
  • Psychology, Biology
    The Australian and New Zealand journal of psychiatry
  • 2001
The dopamine theory of attention deficit hyperactivity disorder (ADHD) in terms of advances made over the last decade is reviewed, and a potential role for α2 noradrenergic agonists such as guanfacine is suggested.