Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions

@article{Villemagne2018ImagingTA,
  title={Imaging tau and amyloid-$\beta$ proteinopathies in Alzheimer disease and other conditions},
  author={V. Villemagne and V. Dor{\'e} and S. Burnham and C. Masters and C. Rowe},
  journal={Nature Reviews Neurology},
  year={2018},
  volume={14},
  pages={225-236}
}
Most neurodegenerative disorders are associated with aggregated protein deposits. In the case of Alzheimer disease (AD), extracellular amyloid-β (Aβ) aggregates and intracellular tau neurofibrillary tangles are the two neuropathological hallmarks of the disease. Aβ-PET imaging has already been approved for clinical use and is being used in clinical trials of anti-Aβ therapies both for patient recruitment and as an outcome measure. These studies have shown that Aβ accumulation is a protracted… Expand
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