Imaging single synaptic vesicles undergoing repeated fusion events: kissing, running, and kissing again

@article{Aravanis2003ImagingSS,
  title={Imaging single synaptic vesicles undergoing repeated fusion events: kissing, running, and kissing again},
  author={Alexander M. Aravanis and Jason L. Pyle and N Charles Harata and Richard W. Tsien},
  journal={Neuropharmacology},
  year={2003},
  volume={45},
  pages={797-813}
}
At synapses of the mammalian central nervous system, release of neurotransmitter occurs at rates transiently as high as 100 Hz, putting extreme demands on nerve terminals with only tens of functional vesicles at their disposal. Thus, the presynaptic vesicle cycle is particularly critical to maintain neurotransmission. To understand vesicle cycling at the most fundamental level, we studied single vesicles undergoing exo/endocytosis and tracked the fate of newly retrieved vesicles. This was… CONTINUE READING

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