Imaging single nanoparticle interactions with human lung cells using fast ion conductance microscopy.

@article{Novak2014ImagingSN,
  title={Imaging single nanoparticle interactions with human lung cells using fast ion conductance microscopy.},
  author={Pavel Novak and Andrew Shevchuk and Pakatip Ruenraroengsak and Michele Miragoli and Andrew J. Thorley and David Klenerman and Max J. Lab and Teresa D. Tetley and Julia Gorelik and Yuri E. Korchev},
  journal={Nano letters},
  year={2014},
  volume={14 3},
  pages={
          1202-7
        }
}
Experimental data on dynamic interactions between individual nanoparticles and membrane processes at nanoscale, essential for biomedical applications of nanoparticles, remain scarce due to limitations of imaging techniques. We were able to follow single 200 nm carboxyl-modified particles interacting with identified membrane structures at the rate of 15 s/frame using a scanning ion conductance microscope modified for simultaneous high-speed topographical and fluorescence imaging. The imaging… CONTINUE READING

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