Imaging rheumatoid arthritis specifically with technetium 99m CD4-specific (T-helper lymphocytes) antibodies

@article{Becker1990ImagingRA,
  title={Imaging rheumatoid arthritis specifically with technetium 99m CD4-specific (T-helper lymphocytes) antibodies},
  author={Wolfgang T Becker and Frank Emmrich and Gerd Horneff and G. R. Burmester and Frank J. Seiler and Alexander Schwarz and Joachim. R. Kalden and Friedrich Wolf},
  journal={European Journal of Nuclear Medicine},
  year={1990},
  volume={17},
  pages={156-159}
}
CD4 expressing T-lymphocytes are involved in the pathogenesis of rheumatoid arthritis, so the possibility of using radiolabelled CD4-specific antibodies to localise diseased joints was studied. Prospectively six patients with rheumatoid arthritis were investigated. Five of them received 200–300 μg of a 555 MBq technetium 99m CD4-specific antibody (MAX.16H5) and were examined with three phase bone scans. Max.16H5 (IgG1) was labelled according to the mercaptoethanol (Schwarz) method. Lymphocytes… CONTINUE READING
13 Citations
13 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 13 references

Therapie der chronischen Polyarthritis mit einem monoklonalen Antik6rper gegen das CD4-Antigen auf T-Helferzellen

  • G Horneff, GR Burmester, G Strobel, M Gramatzki, JR Kalden, F Emmrich
  • Akt Rheumatol
  • 1989
1 Excerpt

Tissue: histocompatibility and immunogenetics

  • F Kissmeyer-Nielsen
  • Munsgaard, Kopenhagen,
  • 1989
1 Excerpt

A novel approach to Tc - 99 - labelled monoclonal antibodies

  • N Matsui, K Nohira, K Suguro, Y Kitakata, G Uchiyama, T Miyoshi
  • J Nucl Med
  • 1987

Empfehlungen fiir die Herstellung und Prfifung in vivo applizierbarer monoklonaler Antik6rper

  • F Emmrich
  • Dtsch Med Wochenschr
  • 1987

Steinstrfisser A (1987) A novel approach to Tc-99labelled monoclonal antibodies

  • A Schwarz
  • J Nucl Med
  • 1987

Radioimmunodetection of cutaneous T-cell lymphoma with In-lll labeled T-101 monoclonal antibody

  • JA Carrasquillo, PA Bunn, +12 authors SM Larson
  • N Engl J Med
  • 1986
1 Excerpt

Similar Papers

Loading similar papers…