Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine.

@article{Pichler2004ImagingRO,
  title={Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine.},
  author={Andrea Pichler and Julie L. Prior and David R. Piwnica-Worms},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 6},
  pages={1702-7}
}
Coelenterazine is widely distributed among marine organisms, producing bioluminescence by calcium-insensitive oxidation mediated by Renilla luciferase (Rluc) and calcium-dependent oxidation mediated by the photoprotein aequorin. Despite its abundance in nature and wide use of both proteins as reporters of gene expression and signal transduction, little is known about mechanisms of coelenterazine transport and cell permeation. Interestingly, coelenterazine analogues share structural and… CONTINUE READING

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