Imaging recollection and familiarity in the medial temporal lobe: a three-component model

@article{Diana2007ImagingRA,
  title={Imaging recollection and familiarity in the medial temporal lobe: a three-component model},
  author={Rachel A. Diana and Andrew P. Yonelinas and Charan Ranganath},
  journal={Trends in Cognitive Sciences},
  year={2007},
  volume={11},
  pages={379-386}
}

Figures and Tables from this paper

The role of recollection and familiarity in the functional differentiation of the medial temporal lobes
TLDR
There has been disagreement about whether recall/recollection is primarily mediated by the hippocampus and familiarity by the evolutionarily newer MTL cortices or whether the MTL mediates these kinds of memory in an integrated, homogeneous fashion.
The contribution of different prefrontal cortex regions to recollection and familiarity: a review of fMRI data
Selective and Shared Contributions of the Hippocampus and Perirhinal Cortex to Episodic Item and Associative Encoding
TLDR
A subsequent memory paradigm that assessed successful item encoding in addition to the encoding of two distinct episodic details, providing strong evidence for a role of the hippocampus in domain-general associative encoding and raising the possibility that PrC encoding operations in conjunction with hippocampal mechanisms contribute to later recollection of presented item details.
Medial Temporal Lobe Activity during Source Retrieval Reflects Information Type, not Memory Strength
TLDR
Results showed that encoding color information as an item detail improved source recognition in amnesic patients with recollection deficits, and qualitatively different patterns of results observed in PRc and hippocampus/PHc are consistent with the idea that different MTL regions process different types of episodic information.
Dissociable neural correlates of item and context retrieval in the medial temporal lobes
Neural correlates of recognition memory for complex visual stimuli in the medial temporal lobe
TLDR
Three experiments were designed to compare competing models of MTL function by measuring, using functional magnetic resonance imaging, the neural correlates of successful recollection- and familiarity-based memory judgements for different types of complex visual stimuli, consistent with views that the perirhinal cortex and hippocampus are differentially involved in processing objects and scenes, rather than in supporting distinct kinds of memory process.
Recollection, familiarity, and content-sensitivity in lateral parietal cortex: a high-resolution fMRI study
TLDR
The findings show that episodic retrieval relies on both content-sensitive and core recollective processes, and these can be differentiated from familiarity-based recognition memory.
...
...

References

SHOWING 1-10 OF 65 REFERENCES
The medial temporal lobe and recognition memory.
TLDR
Evidence from neuropsychological, neuroimaging, and neurophysiological studies of humans, monkeys, and rats indicates that different subregions of the MTL make distinct contributions to recollection and familiarity; the data suggest that the hippocampus is critical for recollection but not familiarity.
Triple dissociation in the medial temporal lobes: recollection, familiarity, and novelty.
TLDR
This is the first study to reveal a triple dissociation within the MTL associated with distinct retrieval processes, and this finding has direct implications for current memory models.
Multiple routes to memory: Distinct medial temporal lobe processes build item and source memories
TLDR
This work used event-related functional MRI to examine the relation between activation in distinct medial temporal lobe subregions during memory formation and the ability to later recognize an item as previously encountered and later recollect specific contextual details about the prior encounter.
Separating the Brain Regions Involved in Recollection and Familiarity in Recognition Memory
TLDR
The neural substrates of recognition memory retrieval were examined in a functional magnetic resonance imaging study to separate activity related to recollection from that related to continuous variations in familiarity, indicating that recollection cannot be attributed to familiarity strength.
Functional-Neuroanatomic Correlates of Recollection: Implications for Models of Recognition Memory
TLDR
Results revealed that multiple left prefrontal cortical regions were engaged during attempts to recollect previous contextual details, regardless of the nature of the to-be-recollected details and of source recollection outcome (successful vs unsuccessful).
Visual presentation of novel objects and new spatial arrangements of objects differentially activates the medial temporal lobe subareas in humans
TLDR
A functional magnetic resonance imaging study to compare the medial temporal lobe responses to changes in object identity and spatial configurations of objects found evidence for the predicted distinction between hippocampal and perirhinal cortical activations, although part of the hippocampus was also activated by identification of novel objects.
Recollection and the reinstatement of encoding-related cortical activity.
TLDR
Content-specific associations between encoding- and recollection-related neural activity strongly support the reinstatement hypothesis of episodic retrieval.
...
...