Imaging peptidoglycan biosynthesis in Bacillus subtilis with fluorescent antibiotics.

@article{Tiyanont2006ImagingPB,
  title={Imaging peptidoglycan biosynthesis in Bacillus subtilis with fluorescent antibiotics.},
  author={Kittichoat Tiyanont and Thierry Doan and Michael B Lazarus and Xiao Fang and David Z Rudner and Suzanne Walker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 29},
  pages={11033-8}
}
The peptidoglycan (PG) layers surrounding bacterial cells play an important role in determining cell shape. The machinery controlling when and where new PG is made is not understood, but is proposed to involve interactions between bacterial actin homologs such as Mbl, which forms helical cables within cells, and extracellular multiprotein complexes that include penicillin-binding proteins. It has been suggested that labeled antibiotics that bind to PG precursors may be useful for imaging PG to… CONTINUE READING

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