Imaging pancreatic cancer using surface-functionalized quantum dots.

@article{Qian2007ImagingPC,
  title={Imaging pancreatic cancer using surface-functionalized quantum dots.},
  author={Jun Qian and Ken-Tye Yong and Indrajit Roy and Tymish Y Ohulchanskyy and Earl J. Bergey and Hoon Hi Lee and Kenneth M. Tramposch and Sailing He and Anirban Maitra and Paras N Prasad},
  journal={The journal of physical chemistry. B},
  year={2007},
  volume={111 25},
  pages={
          6969-72
        }
}
In this study, CdSe/CdS/ZnS quantum dots (QDs) were used as optical contrast agent for imaging pancreatic cancer cells in vitro using transferrin and anti-Claudin-4 as targeting ligands. CdSe/CdS/ZnS was chosen because the CdSe/CdS/ZnS QDs have better photoluminescence (PL) efficiency and stability than those of CdSe/ZnS. The transferrin-mediated targeting is demonstrated in both a cell-free coprecipitation assay as well as using in vitro confocal microscopy. Pancreatic cancer specific uptake… CONTINUE READING

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