Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo.

  title={Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo.},
  author={Andrei V. Zvyagin and Xin Zhao and Audrey Gierden and Washington Sanchez and Justin A. Ross and Michael S. Roberts},
  journal={Journal of biomedical optics},
  volume={13 6},
Zinc oxide (ZnO-nano) and titanium dioxide nanoparticles (20 to 30 nm) are widely used in several topical skin care products, such as sunscreens. However, relatively few studies have addressed the subdermal absorption of these nanoparticles in vivo. We report on investigation of the distribution of topically applied ZnO in excised and in vivo human skin, using multiphoton microscopy (MPM) imaging with a combination of scanning electron microscopy (SEM) and an energy-dispersive x-ray (EDX… CONTINUE READING


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