Imaging of trace elements in tissues: with a focus on laser ablation inductively coupled plasma mass spectrometry

@article{Urgast2014ImagingOT,
  title={Imaging of trace elements in tissues: with a focus on laser ablation inductively coupled plasma mass spectrometry},
  author={Dagmar S. Urgast and John H. Beattie and J{\"o}rg Feldmann},
  journal={Current Opinion in Clinical Nutrition and Metabolic Care},
  year={2014},
  volume={17},
  pages={431–439}
}
Purpose of reviewElemental imaging techniques are capable of showing the spatial distribution of elements in a sample. Their application in biomedical sciences is promising, but they are not yet widely employed. The review gives a short overview about techniques available and then focuses on the advantages of using laser ablation inductively coupled plasma mass spectrometry for elemental bioimaging. Current examples for the use of elemental imaging with medical context are given to illustrate… Expand
9 Citations
Recent applications of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) for biological sample analysis: a follow-up review
Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is a feasible technique to obtain either quantitative elemental data or spatially resolved imaging/mapping of elements inExpand
Laser ablation low-flow ICP-MS for elemental bioimaging
A laser ablation system (LA) was coupled to an in-house developed low-flow inductively coupled plasma ion source for mass spectrometry (ICP-MS). In this setup, the low-flow torch showed bestExpand
Quantitation of the Fe spatial distribution in biological tissue by online double isotope dilution analysis with LA-ICP-MS: a strategy for estimating measurement uncertainty
A novel strategy is reported for the quantitative analysis of the Fe spatial distribution in biological tissue using laser ablation with ICP-MS and on-line double isotope dilution analysisExpand
Atomic Spectrometry Update: review of advances in the analysis of clinical and biological materials, foods and beverages
This review includes publications from November 2012 to September 2013. Microfluidic devices are starting to appear in reports relevant to this ASU. Chip-based technologies were described, performingExpand
Elemental imaging (LA-ICP-MS) of zebrafish embryos to study the toxicokinetics of the acetylcholinesterase inhibitor naled
TLDR
Findings indicate the high reactivity and high transformation rate of naled to other products than dichlorvos and the high reproducibility between replicated and the shift in the Br distribution during exposure. Expand
Characterization of foreign materials in paraffin-embedded pathological specimens using in situ multi-elemental imaging with laser spectroscopy
TLDR
A novel strategy based on laser-induced breakdown spectroscopy (LIBS) technology is evaluated for in situ multi-elemental tissue imaging and the all-optical LIBS elemental imaging instrument that is developed is fully compatible with conventional optical microscopy used for pathology analysis. Expand
Advanced Mass Spectrometry
Abstract Until recently, analytical methods for food safety and quality control had mainly been focused on restricted lists of well-known analytes. Nowadays, in addition to these classical methods,Expand
Correlation of μXRF and LA-ICP-MS in the analysis of a human bone-cartilage sample
In this study we combined μXRF and LA-ICP-MS on the very same human femoral head sample. Obtained spatial elemental distributions within bone and cartilage tissues are accompanied by absoluteExpand
The Position of Metallomics Within Other Omics Fields
Modern analytical techniques, which were developed during the past decades, allowed a remarkable progress of knowledge in biology, biochemistry, and life sciences. The aim of these new technologiesExpand

References

SHOWING 1-10 OF 56 REFERENCES
Quantification strategies for elemental imaging of biological samples using laser ablation-inductively coupled plasma-mass spectrometry.
TLDR
Methods reviewed include the use of CRMs, laboratory prepared matrix matched standards, internal standardisation, online standard addition and a variety of novel approaches that makes elemental imaging accessible to a wider base of analysts. Expand
Trace metal imaging with high spatial resolution: applications in biomedicine.
TLDR
Three common metal imaging techniques in biomedical research are introduced, including synchrotron X-ray fluorescence microscopy, secondary ion mass spectrometry (SIMS), and laser ablation inductively coupled plasma mass spectrumetry (LA-ICP-MS), and these studies have provided solid evidence that demonstrates that the sensitivity, spatial resolution, specificity, and quantification ability of metal Imaging techniques is suitable and highly desirable for biomedical research. Expand
Two-dimensional mapping of copper and zinc in liver sections by laser ablation-inductively coupled plasma mass spectrometry.
BACKGROUND Metals are not homogeneously distributed in organ tissues. Although most mapping techniques, such as histologic staining methods, have been developed for element imaging on a subcellularExpand
Laser ablation based bioimaging with simultaneous elemental and molecular mass spectrometry: towards spatially resolved speciation analysis.
TLDR
The first simultaneous elemental and molecular MS imaging approach based on laser ablation sampling was introduced for spatially resolved speciation analysis, and the combination of the advantages of LA-ICP-MS promises not only localization of metals, but also identification of metal species in biological samples. Expand
Laser ablation ICP-MS for quantitative biomedical applications
TLDR
New developments and most relevant applications of LA-ICP-MS are critically described in this review, with particular emphasis on quantitative strategies currently employ for analysis of proteins in biological tissues. Expand
Comparison of laser ablation-inductively coupled plasma-mass spectrometry and micro-X-ray fluorescence spectrometry for elemental imaging in Daphnia magna.
TLDR
Both techniques for imaging the distribution of selected elements in the model organism Daphnia magna in terms of detection power and spatial resolution are complementary in providing an exhaustive chemical profiling of tissue samples. Expand
A novel calibration strategy for analysis and imaging of biological thin sections by laser ablation inductively coupled plasma mass spectrometry
A novel calibration scheme for elemental analysis and imaging of biological thin sections by laser ablation ICP mass spectrometry is described. The procedure is based on spiking whole blood or bloodExpand
Using laser ablation inductively coupled plasma mass spectrometry to characterize the biointeractions of inhaled CdSe quantum dots in the mouse lungs
Quantum dots (QDs) show great promise for use as drug delivery carriers and fluorescent markers, with potential applications in, for example, pulmonary drug delivery and lung imaging, respectively.Expand
Quantitative imaging of the tissue contrast agent [Gd(DTPA)]²⁻ in articular cartilage by laser ablation inductively coupled plasma mass spectrometry.
TLDR
It is shown for the first time that LA-ICP-MS can be applied to validate the results from quantitative gadolinium-enhanced MRI technique of articular cartilage. Expand
Microanalytical isotope ratio measurements and elemental mapping using laser ablation ICP-MS for tissue thin sections: zinc tracer studies in rats
TLDR
The feasibility to use laser ablation coupled to quadrupole ICP-MS for the determination of zinc tracers given to rats at different time points with the aim to generate isotope ratio bioimages of heart tissue is studied. Expand
...
1
2
3
4
5
...