Imaging of trace elements in tissues: with a focus on laser ablation inductively coupled plasma mass spectrometry

  title={Imaging of trace elements in tissues: with a focus on laser ablation inductively coupled plasma mass spectrometry},
  author={Dagmar S. Urgast and John H. Beattie and J{\"o}rg Feldmann},
  journal={Current Opinion in Clinical Nutrition and Metabolic Care},
Purpose of reviewElemental imaging techniques are capable of showing the spatial distribution of elements in a sample. Their application in biomedical sciences is promising, but they are not yet widely employed. The review gives a short overview about techniques available and then focuses on the advantages of using laser ablation inductively coupled plasma mass spectrometry for elemental bioimaging. Current examples for the use of elemental imaging with medical context are given to illustrate… Expand
9 Citations
Recent applications of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) for biological sample analysis: a follow-up review
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Quantification strategies for elemental imaging of biological samples using laser ablation-inductively coupled plasma-mass spectrometry.
Methods reviewed include the use of CRMs, laboratory prepared matrix matched standards, internal standardisation, online standard addition and a variety of novel approaches that makes elemental imaging accessible to a wider base of analysts. Expand
Trace metal imaging with high spatial resolution: applications in biomedicine.
Three common metal imaging techniques in biomedical research are introduced, including synchrotron X-ray fluorescence microscopy, secondary ion mass spectrometry (SIMS), and laser ablation inductively coupled plasma mass spectrumetry (LA-ICP-MS), and these studies have provided solid evidence that demonstrates that the sensitivity, spatial resolution, specificity, and quantification ability of metal Imaging techniques is suitable and highly desirable for biomedical research. Expand
Two-dimensional mapping of copper and zinc in liver sections by laser ablation-inductively coupled plasma mass spectrometry.
BACKGROUND Metals are not homogeneously distributed in organ tissues. Although most mapping techniques, such as histologic staining methods, have been developed for element imaging on a subcellularExpand
Laser ablation based bioimaging with simultaneous elemental and molecular mass spectrometry: towards spatially resolved speciation analysis.
The first simultaneous elemental and molecular MS imaging approach based on laser ablation sampling was introduced for spatially resolved speciation analysis, and the combination of the advantages of LA-ICP-MS promises not only localization of metals, but also identification of metal species in biological samples. Expand
Laser ablation ICP-MS for quantitative biomedical applications
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Comparison of laser ablation-inductively coupled plasma-mass spectrometry and micro-X-ray fluorescence spectrometry for elemental imaging in Daphnia magna.
Both techniques for imaging the distribution of selected elements in the model organism Daphnia magna in terms of detection power and spatial resolution are complementary in providing an exhaustive chemical profiling of tissue samples. Expand
A novel calibration strategy for analysis and imaging of biological thin sections by laser ablation inductively coupled plasma mass spectrometry
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Quantitative imaging of the tissue contrast agent [Gd(DTPA)]²⁻ in articular cartilage by laser ablation inductively coupled plasma mass spectrometry.
It is shown for the first time that LA-ICP-MS can be applied to validate the results from quantitative gadolinium-enhanced MRI technique of articular cartilage. Expand
Microanalytical isotope ratio measurements and elemental mapping using laser ablation ICP-MS for tissue thin sections: zinc tracer studies in rats
The feasibility to use laser ablation coupled to quadrupole ICP-MS for the determination of zinc tracers given to rats at different time points with the aim to generate isotope ratio bioimages of heart tissue is studied. Expand