Imaging of the muscarinic acetylcholine neuroreceptor in rats with the M2 selective agonist [18F]FP-TZTP.

@article{Ravasi2012ImagingOT,
  title={Imaging of the muscarinic acetylcholine neuroreceptor in rats with the M2 selective agonist [18F]FP-TZTP.},
  author={L. Ravasi and Joji Tokugawa and T. Nakayama and J. Seidel and L. Sokoloff and W. Eckelman and D. Kiesewetter},
  journal={Nuclear medicine and biology},
  year={2012},
  volume={39 1},
  pages={
          45-55
        }
}
  • L. Ravasi, Joji Tokugawa, +4 authors D. Kiesewetter
  • Published 2012
  • Chemistry, Medicine
  • Nuclear medicine and biology
  • INTRODUCTION [(18)F]FP-TZTP is an M2 muscarinic subtype selective receptor-binding radiotracer used in vivo to image human and nonhuman primate brain following both bolus injection and infusion. In order to carry out repeated studies in rodents, the techniques developed for primates must be transferred to rodents with the same precision. This includes obtaining a metabolite-corrected input function. METHODS We compared bolus injection with constant infusion in rats that were awake or under… CONTINUE READING
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    References

    SHOWING 1-10 OF 24 REFERENCES
    Muscarinic Cholinergic Receptor Measurements with [18F]FP-TZTP: Control and Competition Studies
    • 91
    Sensitivity of [11C]N-methylpyrrolidinyl benzilate ([11C]NMPYB) to endogenous acetylcholine: PET imaging vs tissue sampling methods.
    • 13
    Long-term reproducibility of in vivo measures of specific binding of radioligands in rat brain.
    • M. Kilbourn
    • Chemistry, Medicine
    • Nuclear medicine and biology
    • 2004
    • 18
    In vivo binding of (+)-alpha-[3H]dihydrotetrabenazine to the vesicular monoamine transporter of rat brain: bolus vs. equilibrium studies.
    • 18
    Noninvasive Estimation of Normalized Distribution Volume: Application to the Muscarinic-2 Ligand [18F]FP-TZTP
    • M. Ichise, R. Cohen, R. Carson
    • Chemistry, Medicine
    • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    • 2008
    • 18
    Measurement of cerebral glucose metabolic rates in the anesthetized rat by dynamic scanning with 18F-FDG, the ATLAS small animal PET scanner, and arterial blood sampling.
    • 93
    The automated radiosynthesis of [18F]FP-TZTP.
    • 21