Imaging of the Dopamine Presynaptic System by PET: 6-[18F]Fluoro-L-DOPA versus 6-[18F]Fluoro-L-m-tyrosine

  title={Imaging of the Dopamine Presynaptic System by PET: 6-[18F]Fluoro-L-DOPA versus 6-[18F]Fluoro-L-m-tyrosine},
  author={D. Doudet and O. DeJesus and G. Chan and S. Jivan and J. Holden and C. English and T. Aigner and T. Ruth},
The respective advantages and disadvantages of 6-fluoro-L-DOPA (6FD0PA) and 6-fluoro-L-m-tyrosine (6FMT) labeled with 18 F to image the dopamine (DA) presynaptic system in vivo were investigated by positron emission tomography (PET) in normal monkeys and in monkeys with l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced lesions of the DA nigrostriatal neurons. Peripheral metabolism of the radiotracers was analyzed throughout the course of the PET studies. Using a modification of the extended… Expand
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