Imaging of serotonin and dopamine transporters in the living human brain

Abstract

Alterations in brain serotonin (5-HT) and dopamine (DA) activity are associated with several neuropsychiatric disorders, but until now it has not been possible to simultaneously visualize or quantify the 5-HT and the DA transporter density in the living human brain. In this paper we report on the imaging of 5-HT and DA transporters in 28 healthy controls with single-photon emission tomography using iodine-123 labelled 2β-carbomethoxy-3β-(4-iodophenyl)tropane ([123I]β-CIT) as the tracer. The [123I]β-CIT distribution showed the most prominent 5-HT activity in the medial frontal cortex, hypothalamus, midbrain and occipital cortex and the greatest DA activity in the basal ganglia. The specific binding of the 5-HT transporters in the medial frontal cortex was 0.377±0.031 and that of the DA transporters in the basal ganglia, 0.916±0.007. Gjedde-Patlak plots indicated two separate components: the first was assumed to represent 5-HT transporters with a slope of 1.29±0.27 h−1 and the second, DA transporters with a slope of 0.30±0.04 h−1. This distinct kinetic pattern and the fact that 5-HT and DA transporters are situated in different parts of the brain provides an opportunity to study in vivo patients suffering from various neuropsychiatric disorders.

DOI: 10.1007/BF00941852

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@article{Kuikka1995ImagingOS, title={Imaging of serotonin and dopamine transporters in the living human brain}, author={Jyrki T. Kuikka and Jari Tiihonen and Kim A. Bergstr{\"{o}m and Jari Karhu and P{\"a}ivi H Hartikainen and Heimo T Viinam{\"a}ki and Esko A. L{\"a}nsimies and Johannes Lehtonen and Panu Hakola}, journal={European Journal of Nuclear Medicine}, year={1995}, volume={22}, pages={346-350} }