Imaging of peptides in the rat brain using MALDI-FTICR mass spectrometry.

  title={Imaging of peptides in the rat brain using MALDI-FTICR mass spectrometry.},
  author={Ioana M Taban and A F Maarten Altelaar and Yuri E. M. van der Burgt and Liam A McDonnell and Ron M. A. Heeren and Jens Fuchser and G{\"o}khan Baykut},
  journal={Journal of the American Society for Mass Spectrometry},
  volume={18 1},
Analytical methods are pursued to measure the identity and location of biomolecules down to the subcellular (microm) level. Available mass spectrometric imaging methods either compromise localization accuracy or identification accuracy in their analysis of surface biomolecules. In this study, imaging FTICR-MS is applied for the spatially resolved mass analysis of rat brain tissue with the aim to optimize protein identification by the high mass accuracy and online MS/MS capabilities of the… CONTINUE READING

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