Imaging of nucleic acids with atomic force microscopy.

@article{Lyubchenko2011ImagingON,
  title={Imaging of nucleic acids with atomic force microscopy.},
  author={Yuri L Lyubchenko and L. S. Shlyakhtenko and Toshio Ando},
  journal={Methods},
  year={2011},
  volume={54 2},
  pages={274-83}
}
Atomic force microscopy (AFM) is a key tool of nanotechnology with great importance in applications to DNA nanotechnology and to the recently emerging field of RNA nanotechnology. Advances in the methodology of AFM now enable reliable and reproducible imaging of DNA of various structures, topologies, and DNA and RNA nanostructures. These advances are reviewed here with emphasis on methods utilizing modification of mica to prepare the surfaces enabling reliable and reproducible imaging of DNA… CONTINUE READING