Imaging of non-tumorous and tumorous human brain tissues with full-field optical coherence tomography☆

@article{Assayag2013ImagingON,
  title={Imaging of non-tumorous and tumorous human brain tissues with full-field optical coherence tomography☆},
  author={Osnath Assayag and Kate Grieve and Bertrand Devaux and Fabrice Harms and Johan Pallud and Fabrice Chr{\'e}tien and Claude A. Boccara and Pascale Varlet},
  journal={NeuroImage : Clinical},
  year={2013},
  volume={2},
  pages={549 - 557}
}

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References

SHOWING 1-10 OF 55 REFERENCES

Imaging of human brain tumor tissue by near-infrared laser coherence tomography

TLDR
This feasibility study has demonstrated that OCT analysis of the tissue microstructure and light attenuation characteristics discriminate normal brain, areas of tumor infiltrated brain, solid tumor, and necrosis.

Optical coherence tomography for neurosurgical imaging of human intracortical melanoma.

TLDR
OCT can effectively differentiate normal cortex from intracortical melanoma based on variations in optical backscatter, and may permit the intraoperative identification of tumor and the more precise localization of tumor margins.

Imaging ex vivo healthy and pathological human brain tissue with ultra-high-resolution optical coherence tomography.

TLDR
The ability of UHR OCT to visualize and identify morphological features such as microcalcifications, enlarged nuclei of tumor cells, small cysts, and blood vessels, which are characteristic of neuropathologies and normally absent in healthy brain tissue are demonstrated.

Large Field, High Resolution Full-Field Optical Coherence Tomography

TLDR
High-resolution Full-Field Optical Coherence Tomography (FF-OCT) was used to image human breast tissue and is evaluated to assess its ability to aid the pathologist's management of intra-operative diagnoses.

Intraoperative Confocal Microscopy for Brain Tumors: A Feasibility Analysis in Humans

TLDR
Preliminary analysis demonstrates reliability for a variety of lesions in identifying tumor cells and the tumor-brain interface in intraoperative confocal microscopy for brain tumor resection.

Identifying brain neoplasms using dye-enhanced multimodal confocal imaging.

TLDR
Multimodal confocal imaging has the potential to aid in the intraoperative detection of microscopic deposits of brain neoplasms and the application of this technique may improve completeness of resection and increase patient survival.

Benign and malignant lesions in the human breast depicted with ultrahigh resolution and three-dimensional optical coherence tomography.

TLDR
Imaging of ductal carcinoma in situ, infiltrating cancer, and microcalcifications correlated with corresponding histopathologic findings showed OCT is potentially useful for visualization of breast lesions at a resolution greater than that of currently available clinical imaging methods.

Intraoperative evaluation of breast tumor margins with optical coherence tomography.

TLDR
Results show the potential of OCT as a real-time method for intraoperative margin assessment in breast-conserving surgeries and areas of higher scattering tissue with a heterogeneous pattern were indicative of tumor cells and tumor tissue in contrast to lower scattering adipocytes found in normal breast tissue.

Multimodal full-field optical coherence tomography on biological tissue: toward all optical digital pathology

TLDR
A multimodal approach to FF-OCT is reported, combining two Full-Field techniques for collecting a backscattered endogeneous OCT image and a fluorescence exogeneous image in parallel, and paves the way for improvements of standard pathology procedures, as a faster, non sacrificial, operator independent digital optical method compared to frozen sections.

Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues.

TLDR
The results lay the foundation for future in vivo optical evaluation of breast tissues, using OCT and OCM, which has the potential to guide core needle biopsies, assess surgical margins, and evaluate nodal involvement in breast cancer.
...