Imaging of delta- and mu-opioid receptors in temporal lobe epilepsy by positron emission tomography.

@article{Madar1997ImagingOD,
  title={Imaging of delta- and mu-opioid receptors in temporal lobe epilepsy by positron emission tomography.},
  author={Igal Madar and Ronald Peter Lesser and Gregory Krauss and Jon Kar Zubieta and John R. Lever and C M Kinter and Hayden T. Ravert and John L. Musachio and William B Mathews and Robert F. Dannals and James Frost},
  journal={Annals of neurology},
  year={1997},
  volume={41 3},
  pages={358-67}
}
The involvement of opioid neurotransmitter systems in seizure mechanisms is well documented. In previous positron emission tomography (PET) studies in patients with unilateral temporal lobe epilepsy, we have found evidence for differential regulation of the opioid-receptor subtypes. The present study extends our previous observations to delta-opioid receptors by using the delta-receptor-selective antagonist [11C]methylnaltrindole ([11C]MeNTI). Paired measurements of delta- and mu-opioid… CONTINUE READING