Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with 18F-DPA-714 and micro-PET/CT

  title={Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with 18F-DPA-714 and micro-PET/CT},
  author={Sara Gargiulo and Serenella Anzilotti and Anna Rita Daniela Coda and Matteo Gramanzini and Adelaide Greco and Maria Rosaria Panico and Agatino Vinciguerra and Antonella Zannetti and Caterina Vicidomini and Fr{\'e}d{\'e}ric Doll{\'e} and Giuseppe Pignataro and Mario Quarantelli and Lucio Annunziato and Arturo Brunetti and Marco Salvatore and Sabina Pappat{\`a}},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
PurposeTo evaluate the feasibility and sensitivity of 18F-DPA-714 for the study of microglial activation in the brain and spinal cord of transgenic SOD1G93A mice using high-resolution PET/CT and to evaluate the Iba1 and TSPO expression with immunohistochemistry.MethodsNine symptomatic SOD1G93A mice (aged 117 ± 12.7 days, clinical score range 1 – 4) and five WT SOD1 control mice (aged 108 ± 28.5 days) underwent 18F-DPA-714 PET/CT. SUV ratios were calculated by normalizing the cerebellar (rCRB… 

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