Imaging of bioluminescent LNCaP-luc-M6 tumors: a new animal model for the study of metastatic human prostate cancer.

@article{Scatena2004ImagingOB,
  title={Imaging of bioluminescent LNCaP-luc-M6 tumors: a new animal model for the study of metastatic human prostate cancer.},
  author={Caroline D. Scatena and Mischa A Hepner and Yoko A Oei and Joan M Dusich and S Yu and Tony F Purchio and Pamela R. Contag and Darlene E. Jenkins},
  journal={The Prostate},
  year={2004},
  volume={59 3},
  pages={292-303}
}
BACKGROUND Animal experiments examining hormone-sensitive metastatic prostate cancer using the human LNCaP cell line have been limited to endpoint analyses. To permit longitudinal studies, we generated a luciferase-expressing cell line and used bioluminescent imaging (BLI) to non-invasively monitor the in vivo growth of primary LNCaP tumors and metastasis. METHODS LNCaP.FGC cells were transfected to constitutively express firefly luciferase. LNCaP-luc-M6 cells were tested for bioluminescent… CONTINUE READING