Imaging of basal cell carcinoma by high‐definition optical coherence tomography: histomorphological correlation. A pilot study

  title={Imaging of basal cell carcinoma by high‐definition optical coherence tomography: histomorphological correlation. A pilot study},
  author={Marc Boone and S Norrenberg and Gregor Borut Ernst Jemec and V{\'e}ronique del Marmol},
  journal={British Journal of Dermatology},
Summary Background  With the continued development of noninvasive therapies for basal cell carcinoma (BCC) such as photodynamic therapy and immune therapies, noninvasive diagnosis and monitoring become increasingly relevant. High‐definition optical coherence tomography (HD‐OCT) is a high‐resolution imaging tool, with micrometre resolution in both transversal and axial directions, enabling visualization of individual cells up to a depth of around 570 μm, and filling the imaging gap between… 
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High‐definition optical coherence tomography algorithm for discrimination of basal cell carcinoma from clinical BCC imitators and differentiation between common subtypes
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Imaging actinic keratosis by high‐definition optical coherence tomography. Histomorphologic correlation: a pilot study
The study implies that high‐definition optical coherence tomography facilitates in vivo diagnosis of actinic keratosis and allows the grading of different actinic Keratosis lesions for increased clinical utility.
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Preliminary studies described morphological features of actinic keratosis (AK) and squamous cell carcinoma (SCC) imaged by High‐Definition Optical Coherence Tomography (HD‐OCT) and suggested that
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Optical coherence tomography (OCT) is a noninvasive near‐infrared light imaging technology that can be utilized to diagnose basal cell carcinomas (BCCs) based on specific morphological features.
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Potentially noninvasive imaging techniques, such as optical coherence tomography (OCT), may be useful to diagnose and manage patients with sBCC and obviate the need for biopsy.
Optical coherence tomography of actinic keratoses and basal cell carcinomas – differentiation by quantification of signal intensity and layer thickness
There is a lack of systematic studies that give standardized information on signal intensity and layer thickness of AKs and BCCs, so there is a need for more studies to be conducted on this topic.
Histopathological correlates of basal cell carcinoma in the slice and en face imaging modes of high‐definition optical coherence tomography
High‐definition optical coherence tomography (HD‐OCT) scanners have recently been developed, providing significantly higher resolution than conventional OCT, and are being developed for clinical use.


In vivo thickness measurement of basal cell carcinoma and actinic keratosis with optical coherence tomography and 20‐MHz ultrasound
Imaging with optical coherence tomography (OCT) has the potential to diagnose and measure depth of nonmelanoma skin cancer.
In vivo optical coherence tomography of basal cell carcinoma.
Optical Coherence Tomography Used as a Modality to Delineate Basal Cell Carcinoma prior to Mohs Micrographic Surgery
Using OCT to delineate the apparent sub-surface margins of NMSC lesions prior to their excision by MMS exhibits excellent correlation with the MMS defect.
Correlation of Thickness of Basal Cell Carcinoma by Optical Coherence Tomography In Vivo and Routine Histologic Findings: A Pilot Study
Optical coherence tomography, compared with routine histopathologic techniques, shows promise as a method for estimating the superficial thickness of basal cell carcinoma.
Diagnosis of Nonmelanoma Skin Cancer/Keratinocyte Carcinoma: A Review of Diagnostic Accuracy of Nonmelanoma Skin Cancer Diagnostic Tests and Technologies
  • M. Mogensen, G. Jemec
  • Medicine
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • 2007
Some new imaging technologies have the capability of providing new, three-dimensional in vivo, in situ understanding of NMSC development over time and have the potential to make it from the bench to the clinic.
Real-time, in vivo confocal reflectance microscopy of basal cell carcinoma.
Near-infrared confocal microscopy may facilitate diagnosis of basal cell carcinoma with the use of in vivo high-resolution confocal features and accuracy studies to evaluate these in vivo histologic criteria are warranted.
Reflectance confocal microscopy of pigmented basal cell carcinoma.
Assessment of Optical Coherence Tomography Imaging in the Diagnosis of Non‐Melanoma Skin Cancer and Benign Lesions Versus Normal Skin: Observer‐Blinded Evaluation by Dermatologists and Pathologists
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