Imaging of T-cell receptor fused to CD3ζ reveals enhanced expression and improved pairing in living cells.

Abstract

T cell receptor (TCR) gene adoptive therapy is a promising clinical approach for the treatment of malignant tumors and viral diseases. However, the effectiveness of this strategy is hampered by the generation of mixed TCR heterodimers comprising both exogenous and endogenous TCR chains (i.e., mispairing of TCR chains). In the present study, we constructed… (More)
DOI: 10.3892/ijmm.2014.1839

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@article{Tao2014ImagingOT, title={Imaging of T-cell receptor fused to CD3ζ reveals enhanced expression and improved pairing in living cells.}, author={Changli Tao and Hongwei Shao and Yin Yuan and Hui Wang and Wenfeng Zhang and Wenling Zheng and Wenli Ma and Shulin Huang}, journal={International journal of molecular medicine}, year={2014}, volume={34 3}, pages={849-55} }