Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.

@article{Meister2011ImagingOP,
  title={Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.},
  author={Stephan Meister and David M. Plouffe and Kelli L. Kuhen and Ghislain M C Bonamy and Tao Wu and S. Whitney Barnes and Selina E. R. Bopp and Rachel Borboa and Andrew Bright and Jianwei Che and Steve J. Cohen and Neekesh V. Dharia and Kerstin Gagaring and Montip Gettayacamin and Perry Gordon and Todd Groessl and Nobutaka Kato and Marcus C S Lee and Case W. McNamara and David A. Fidock and Advait Nagle and Tae-Gyu Nam and Wendy Richmond and Jason Roland and Matthias Rottmann and Bin Zhou and Patrick Froissard and Richard J. Glynne and Dominique Mazier and Jetsumon Sattabongkot and Peter G. Schultz and Tove Tuntland and John R. Walker and Yingyao Zhou and Arnab Chatterjee and Thierry Tidiane Diagana and Elizabeth A. Winzeler},
  journal={Science},
  year={2011},
  volume={334 6061},
  pages={1372-7}
}
Most malaria drug development focuses on parasite stages detected in red blood cells, even though, to achieve eradication, next-generation drugs active against both erythrocytic and exo-erythrocytic forms would be preferable. We applied a multifactorial approach to a set of >4000 commercially available compounds with previously demonstrated blood-stage activity (median inhibitory concentration < 1 micromolar) and identified chemical scaffolds with potent activity against both forms. From this… CONTINUE READING
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