Imaging of P glycoprotein function in vivo with PET.

  title={Imaging of P glycoprotein function in vivo with PET.},
  author={N. Harry Hendrikse and Willem Vaalburg},
  journal={Novartis Foundation symposium},
  pages={137-45; discussion 145-8, 180-5}
P glycoprotein (Pgp) is expressed on cell membranes of various organs in the body, such as the capillary endothelial cells of the brain. Furthermore, Pgp can also be expressed on the cell membrane of tumour cells. Because of Pgp-mediated efflux, tissue levels of several Pgp substrates are lower than in Pgp-negative tissues. Drug levels in Pgp-expressing organs may be increased by modulation of this Pgp-facilitated transport with several compounds, such as cyclosporin A. Up to now, the presence… CONTINUE READING