Imaging of HSV-tk Reporter gene expression: comparison between [18F]FEAU, [18F]FFEAU, and other imaging probes.

@article{Miyagawa2008ImagingOH,
  title={Imaging of HSV-tk Reporter gene expression: comparison between [18F]FEAU, [18F]FFEAU, and other imaging probes.},
  author={Tadashi Miyagawa and George L. Gogiberidze and Inna S Serganova and Shangde Cai and Julius Balatoni and Howard T. Thaler and Lyudmila Ageyeva and Nagavarakishore Pillarsetty and Ronald D. Finn and Ronald G. Blasberg},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2008},
  volume={49 4},
  pages={637-48}
}
UNLABELLED Herpes virus type 1 thymidine kinase (HSV1-tk) and the mutant HSV1-sr39tk are the 2 most widely used "reporter genes" for radiotracer-based imaging. Two pyrimidine nucleoside analogs, [18F]FEAU (1-(2'-deoxy-2'-fluoro-beta-d-arabinofuranosyl)-5-ethyluridine) and [18F]FFEAU (1-(2'-deoxy-2'-fluoro-beta-d-arabinofuranosyl)-5-(2-fluoroethyl)uridine), have generated recent interest as potential new probes for imaging HSV1-tk and HSV1-sr39tk gene expression. METHODS We compared [18F]FEAU… CONTINUE READING