Imaging of EdU, an alkyne-tagged cell proliferation probe, by Raman microscopy.

@article{Yamakoshi2011ImagingOE,
  title={Imaging of EdU, an alkyne-tagged cell proliferation probe, by Raman microscopy.},
  author={Hiroyuki Yamakoshi and Kosuke Dodo and Masaya Okada and Jun Ando and Almar Flotildes Palonpon and Katsumasa Fujita and Satoshi Kawata and Mikiko Sodeoka},
  journal={Journal of the American Chemical Society},
  year={2011},
  volume={133 16},
  pages={6102-5}
}
Click-free imaging of the nuclear localization of an alkyne-tagged cell proliferation probe, EdU, in living cells was achieved for the first time by means of Raman microscopy. The alkyne tag shows an intense Raman band in a cellular Raman-silent region that is free of interference from endogenous molecules. This approach may eliminate the need for click reactions in the detection of alkyne-labeled molecules. 
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For the original work on the use of EdU for the measurement of DNA synthesis , see : ( a )

  • C. G. Hahn, L. Y. Han, +4 authors S. E. Arnold
  • J . Comput . Neurol .
  • 2005

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