Imaging neural circuit dynamics with a voltage-sensitive fluorescent protein.

@article{Akemann2012ImagingNC,
  title={Imaging neural circuit dynamics with a voltage-sensitive fluorescent protein.},
  author={W. Akemann and H. Mutoh and Am{\'e}lie Perron and Y. K. Park and Y. Iwamoto and T. Kn{\"o}pfel},
  journal={Journal of neurophysiology},
  year={2012},
  volume={108 8},
  pages={
          2323-37
        }
}
  • W. Akemann, H. Mutoh, +3 authors T. Knöpfel
  • Published 2012
  • Medicine, Psychology
  • Journal of neurophysiology
  • Population signals from neuronal ensembles in cortex during behavior are commonly measured with EEG, local field potential (LFP), and voltage-sensitive dyes. A genetically encoded voltage indicator would be useful for detection of such signals in specific cell types. Here we describe how this goal can be achieved with Butterfly, a voltage-sensitive fluorescent protein (VSFP) with a subthreshold detection range and enhancements designed for voltage imaging from single neurons to brain in vivo… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 70 REFERENCES
    Imaging brain electric signals with genetically targeted voltage-sensitive fluorescent proteins
    230
    Red-shifted voltage-sensitive fluorescent proteins.
    78
    Effect of voltage sensitive fluorescent proteins on neuronal excitability.
    65
    Long-term voltage-sensitive dye imaging reveals cortical dynamics in behaving monkeys.
    188
    Genetically encoded probes for optical imaging of brain electrical activity.
    25
    Millisecond-timescale, genetically targeted optical control of neural activity
    3296