Imaging nanometer domains of β-adrenergic receptor complexes on the surface of cardiac myocytes

@article{Ianoul2005ImagingND,
  title={Imaging nanometer domains of β-adrenergic receptor complexes on the surface of cardiac myocytes},
  author={Anatoli Ianoul and Donna D Grant and Yanouchka Rouleau and Mahmud Bani-Yaghoub and Linda J Johnston and John Paul Pezacki},
  journal={Nature Chemical Biology},
  year={2005},
  volume={1},
  pages={196-202}
}
The contraction of cardiac myocytes is initiated by ligand binding to adrenergic receptors1,2 contained in nanoscale multiprotein complexes called signalosomes3. The composition and number of functional signalosomes within cardiac myocytes defines the molecular basis of the response to adrenergic stimuli3,4,5,6. For the first time, we demonstrated the ability of near-field scanning optical microscopy to visualize β-adrenergic receptors at the nanoscale in situ. On H9C2 cells, mouse neonatal and… CONTINUE READING
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