Imaging mass spectrometry demonstrates age-related decline in human adipose plasticity.

  title={Imaging mass spectrometry demonstrates age-related decline in human adipose plasticity.},
  author={Christelle Guillermier and Pouneh K. Fazeli and Soo M Kim and Mingyue Lun and Jonah P. Zuflacht and Jessica Milian and Hang Lee and Hugues Francois-Saint-Cyr and François Horr{\'e}ard and David J. Larson and Evan D. Rosen and Richard T. Lee and Claude P. Lechene and Matthew L. Steinhauser},
  journal={JCI insight},
  volume={2 5},
Quantification of stable isotope tracers has revealed the dynamic state of living tissues. [] Key Method In a first-in-human study, we utilize stable isotope tracers of DNA synthesis and de novo lipogenesis to prospectively measure cell birth and adipocyte lipid turnover. In a study of healthy adults, we elucidate an age-dependent decline in new adipocyte generation and adipocyte lipid turnover. A linear regression model suggests that the aging effect could be mediated by a decline in insulin-like growth…

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