Imaging localised dynamic changes in the nucleus accumbens following nicotine withdrawal in rats

@article{Shoaib2004ImagingLD,
  title={Imaging localised dynamic changes in the nucleus accumbens following nicotine withdrawal in rats},
  author={Mohammed Shoaib and Andrew S. Lowe and Steven C. R. Williams},
  journal={NeuroImage},
  year={2004},
  volume={22},
  pages={847-854}
}
This study utilises pharmacological functional magnetic resonance imaging (fMRI) to examine the neurobiological mechanisms through which nicotine produces dependence. Using an established regime to induce physical dependence to nicotine in rats (osmotic minipumps delivering 3.16 mg/kg/day nicotine for 7 days SC), animals were subsequently anaesthetised under urethane and positioned in a stereotaxic frame to allow collection of gradient echo whole brain images with a 4.7-T MRI spectrometer. Rats… Expand
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