Imaging localised dynamic changes in the nucleus accumbens following nicotine withdrawal in rats

  title={Imaging localised dynamic changes in the nucleus accumbens following nicotine withdrawal in rats},
  author={M. Shoaib and A. S. Lowe and S. Williams},
  • M. Shoaib, A. S. Lowe, S. Williams
  • Published 2004
  • Computer Science, Medicine, Psychology
  • NeuroImage
  • This study utilises pharmacological functional magnetic resonance imaging (fMRI) to examine the neurobiological mechanisms through which nicotine produces dependence. Using an established regime to induce physical dependence to nicotine in rats (osmotic minipumps delivering 3.16 mg/kg/day nicotine for 7 days SC), animals were subsequently anaesthetised under urethane and positioned in a stereotaxic frame to allow collection of gradient echo whole brain images with a 4.7-T MRI spectrometer. Rats… CONTINUE READING
    30 Citations
    Region-Specific Effects of Nicotine on Brain Activity: A Pharmacological MRI Study in the Drug-Naïve Rat
    • 68
    • PDF
    Peculiar response to methylphenidate in adolescent compared to adult rats: a phMRI study
    • 33
    Neuroadaptive responses to citalopram in rats using pharmacological magnetic resonance imaging
    • 21
    Deficits in a sustained attention task following nicotine withdrawal in rats
    • 77
    In vivo brain imaging of human exposure to nicotine and tobacco.
    • 74
    • PDF
    Neuroanatomical targets of reboxetine and bupropion as revealed by pharmacological magnetic resonance imaging
    • 8
    Functional brain imaging of tobacco use and dependence.
    • A. Brody
    • Psychology, Medicine
    • Journal of psychiatric research
    • 2006
    • 163


    Nicotine-induced limbic cortical activation in the human brain: a functional MRI study.
    • 454
    Lack of tolerance to nicotine-induced dopamine release in the nucleus accumbens.
    • 176
    Effects of nicotine withdrawal on central dopaminergic systems
    • 105
    Pharmacological applications of magnetic resonance imaging.
    • 61