Imaging live cell membranes via surface plasmon-enhanced fluorescence and phase microscopy.

@article{He2010ImagingLC,
  title={Imaging live cell membranes via surface plasmon-enhanced fluorescence and phase microscopy.},
  author={Ruei-Yu He and C A Lin and Y D Su and Kuo-Chih Chiu and Nan-Shan Chang and H. -C. Wu and Shean-Jen Chen},
  journal={Optics express},
  year={2010},
  volume={18 4},
  pages={3649-59}
}
This paper demonstrates the first combination for wide-field surface plasmon (SP) phase microscopy and SP-enhanced fluorescence microscopy to image living cells' contacts on the surface of a bio-substrate simultaneously. The phase microscopy with a phase-shift interferometry and common-path optical setup can provide high-sensitivity phase information in long-term stability. Simultaneously, the fluorescence microscopy with the enhancement of a local electromagnetic field can supply bright… CONTINUE READING