Imaging input and output of neocortical networks in vivo.

  title={Imaging input and output of neocortical networks in vivo.},
  author={Jason N. D. Kerr and David S. Greenberg and Fritjof Helmchen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 39},
Neural activity manifests itself as complex spatiotemporal activation patterns in cell populations. Even for local neural circuits, a comprehensive description of network activity has been impossible so far. Here we demonstrate that two-photon calcium imaging of bulk-labeled tissue permits dissection of local input and output activities in rat neocortex in vivo. Besides astroglial and neuronal calcium transients, we found spontaneous calcium signals in the neuropil that were tightly correlated… CONTINUE READING
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