Imaging in multiple sclerosis: A new spin on lesions

  title={Imaging in multiple sclerosis: A new spin on lesions},
  author={Rayan Bou Fakhredin and Charbel Saade and Racha Kerek and Lara El-Jamal and Samia J. Khoury and Fadi El-Merhi},
  journal={Journal of Medical Imaging and Radiation Oncology},
This article evaluates the most relevant state‐of‐the‐art magnetic resonance (MR) techniques that are clinically available to investigate multiple sclerosis (MS). The presence of hypo‐ and hyperintense lesions on T1‐ and T2‐weighted magnetic resonance imaging (MRI) sequences in white matter (WM) is a common finding that is occasionally a diagnostic challenge for the radiologist. The technical requirements and how they may help to understand, classify or follow‐up these pathologies are briefly… 

Case Report Multiple Sclerosis

A 31 year-old woman with the main complaint of weakness of four extremities accompanied by a decreased vision and impaired urination and bowel movement is diagnosed with suspected multiple sclerosis and treated with intravenous steroids.

Gadolinium and Multiple Sclerosis: Vessels, Barriers of the Brain, and Glymphatics

The aim of this review was to outline the pathophysiology of the effect of lymphocyte-driven inflammation in MS, to describe the effects of gadolinium on the BBB and glymphatic system, and to describe gadolinia enhancement patterns and artifacts that can mimic lesions in MS.

Quantifying the Metabolic Signature of Multiple Sclerosis by in vivo Proton Magnetic Resonance Spectroscopy: Current Challenges and Future Outlook in the Translation From Proton Signal to Diagnostic Biomarker

The existing findings of in vivo 1H-MRS on central nervous system metabolic abnormalities in multiple sclerosis and its subtypes are reviewed within the context of study design, spectral acquisition and processing, and metabolite quantification and an outlook on technical considerations is offered.

Laboratory Biomarkers of Multiple Sclerosis (MS).

An Exposure-Response Analysis of the Clinical Efficacy of Ponesimod in a Randomized Phase II Study in Patients with Multiple Sclerosis

Sex, age, T1 Gd+ lesions at baseline, and Expanded Disability Status Score at baseline were not found to be importantly associated with the magnitude of ponesimod effect, and consequently, there is no indication from these analyses that dosage adjustments based on the explored covariates are warranted.

Demyelinating Diseases: Multiple Sclerosis

Demyelination is characterized by destruction of normal myelin with an elative preservation of axons. Demyelinating diseases encompass among others multiple sclerosis (MS), neuromyelitis optica

Continuing Professional Development

  • Medicine
    Journal of medical imaging and radiation oncology
  • 2017
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Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis

At autopsy the brain of a patient with chronic progressive multiple sclerosis who suffered acute worsening leading to death showed new Gd‐DTPA‐enhanced lesions in the posterior hemispheric white matter adjacent to the lateral ventricles, and these were found to be fresh lesions comprising intense inflammatory activity and dense perivascular cuffs within an edematous lesion center.

High field MR imaging and 1H-MR spectroscopy in clinically isolated syndromes suggestive of multiple sclerosis

A significant axonal damage already occurs during the first demyelinating episode in patients with CIS as assessed by 1H-MRS, suggesting that conventional MR imaging in terms of diagnostic imaging criteria does not significantly reflect NAWM disease activity in Terms of metabolic alterations detected by1H-MR spectroscopy.

Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis

It is concluded that, in a limited sample, hypointense lesions seen on T1-weighted SE MR images are associated histopathologically with severe tissue destruction, including axonal loss.

The lesion in multiple sclerosis: clinical, pathological, and magnetic resonance imaging considerations.

  • H. Mcfarland
  • Medicine, Psychology
    Journal of neurology, neurosurgery, and psychiatry
  • 1998
MRI and pathological studies now indicate that damage to the axon may occur earlier in lesion development than generally thought, and considerable attention is now focused on studying newer techniques that should provide greater insight into lesions development.

Prognostic value of high-field proton magnetic resonance spectroscopy in patients presenting with clinically isolated syndromes suggestive of multiple sclerosis

Axonal damage at baseline in patients presenting with CIS was more prominent in those who subsequently converted to definite MS in the short term follow-up, indicating that tNAA might be a sufficient prognostic marker for patients with a higher risk of conversion to early definite MS.

Gray- and white-matter changes 1 year after first clinical episode of multiple sclerosis: MR imaging.

WM damage was detectable early and involved most fiber tracts in patients with MS, but it did not worsen significantly during the 1st year after clinical onset, and a significant decrease in cortical and deep GM volume was observed at 1 year.

Magnetic resonance imaging measures of brain atrophy in multiple sclerosis

Brain atrophy has been incorporated as an outcome measure in therapeutic trials of disease‐modifying treatments and the findings of natural‐history and therapeutic studies, and the future research directions and clinical applications of brain atrophy measurements are considered.

Double inversion recovery brain imaging at 3T: diagnostic value in the detection of multiple sclerosis lesions.

DIR brain imaging at 3T provides the highest sensitivity in the detection of MS lesions especially in the infratentorial region.

Relevance of hypointense brain MRI lesions for long-term worsening of clinical disability in relapsing multiple sclerosis

In RRMS patients, long-term brain lesion accrual is associated with worsening in clinical disability, particularly true for hypointense, destructive lesions.