Imaging glycans in zebrafish embryos by metabolic labeling and bioorthogonal click chemistry.


Imaging glycans in vivo has recently been enabled using a bioorthogonal chemical reporter strategy by treating cells or organisms with azide- or alkyne-tagged monosaccharides. The modified monosaccharides, processed by the glycan biosynthetic machinery, are incorporated into cell surface glycoconjugates. The bioorthogonal azide or alkyne tags then allow… (More)
DOI: 10.3791/2686


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