Imaging genetics.

  title={Imaging genetics.},
  author={Karen E. Mu{\~n}oz and Luke W. Hyde and Ahmad R. Hariri},
  journal={Journal of the American Academy of Child and Adolescent Psychiatry},
  volume={48 4},
As research in developmental and clinical sciences has progressed in the last decades, there have been many important technological and methodological advances in the increasingly complimentary fields of molecular genetics and neuroimaging. These advances have facilitated fruitful collaboration across once disparate disciplines, with early results shedding new light on the mechanisms giving rise to individual differences in complex behaviors and related psychiatric disorders. At the leading… 
Developmental psychopathology in an era of molecular genetics and neuroimaging: A developmental neurogenetics approach
  • L. Hyde
  • Psychology, Biology
    Development and Psychopathology
  • 2015
How neurogenetics and current imaging and molecular genetics approaches can be incorporated into developmental psychopathology perspectives with a goal of providing models for better understanding pathways from among genes, environments, the brain, and behavior is discussed.
Imaging the genetics of brain structure and function
Associations between brain abnormalities and common genetic variants for schizophrenia: a narrative review of structural and functional neuroimaging findings.
A summary of current progress in neuroimaging findings to detect genetic variants that may influence the brain's structure and function, and thus improve understanding of how this interaction affects the onset of schizophrenia is provided.
Neuroimaging and genetic risk for Alzheimer’s disease and addiction-related degenerative brain disorders
It is described how multi-modal imaging can be used to study the changing brain during the different stages of AD, integrating findings from a range of studies using magnetic resonance imaging (MRI), positron emission tomography (PET), functional MRI (fMRI) and diffusion weighted imaging (DWI).
An imaging genetics approach to understanding social influence
It is suggested that genetic variants that increase sensitivity to social cues may predispose individuals to be more sensitive to either social rewards or punishments, which in turn increases conformity and susceptibility to normative social influences more broadly.
Joint-Connectivity-Based Sparse Canonical Correlation Analysis of Imaging Genetics for Detecting Biomarkers of Parkinson’s Disease
A connectivity-based penalty for incorporating biological prior information is proposed for sparse canonical correlation analysis (SCCA) to improve the efficiency and interpretability of SCCA and can handle multi-modal neuroimaging datasets.
Cultural neuroscience: new directions as the field matures
Open questions regarding the stability versus malleability of findings across time, environments, and cultural settings are highlighted and ways in which cultural neuroscience can inform a broader understanding of the development of differences in complex behaviors are highlighted.
Seeking Optimal Region-Of-Interest (ROI) Single-Value Summary Measures for fMRI Studies in Imaging Genetics
Results show that four measures, particularly those that represent values from the top most-activated voxels within an ROI are more powerful at reliably detecting group differences and generating greater effect sizes than the others.


Developmental imaging genetics: Challenges and promises for translational research
An experimental strategy by which genetic effects on brain function can be explored using neuroimaging, namely, imaging genetics is outlined, and some major findings in imaging genetics are described to highlight the effectiveness of this strategy for delineating biological pathways and mechanisms by which individual differences in brain function emerge and potentially bias behavior and risk for psychiatric illness.
Identification of neurogenetic pathways of risk for psychopathology
Recent multimodal neuroimaging strategies and studies examining the effects of multiple genes in concert within large subject populations have shown promise in the development of a more complete understanding of the interrelationships between genes, brain function, behavior and associated risk for psychopathology.
Imaging genomics.
All of these biological relationships have been revealed in relatively small samples of healthy volunteers and in the absence of observable differences at the level of behaviour, underscoring the power of a direct assay of brain physiology like fMRI in exploring the functional impact of genetic variation.
At issue: genes, experience, and chance in schizophrenia--positioning for the 21st century.
A blueprint for future genetic research and informed dissemination of findings to the public and to lawmakers is discussed, and specific misconceptions about the genetics of schizophrenia held by many in the scientific community and in the media are addressed.
The genetic basis of complex human behaviors.
Quantitative genetic research has built a strong case for the importance of genetic factors in many complex behavioral disorders and dimensions in the domains of psychopathology, personality, and
Benefits and pitfalls encountered in psychiatric genetic association studies
Association analysis of candidate genes for neuropsychiatric disease: the perpetual campaign.
Gene–environment interactions in psychiatry: joining forces with neuroscience
Opportunities and challenges in the collaboration between psychiatry, epidemiology and neuroscience in studying gene–environment interactions in psychiatry are discussed.
Dynamic mapping of human cortical development during childhood through early adulthood.
  • N. Gogtay, J. Giedd, P. Thompson
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
The dynamic anatomical sequence of human cortical gray matter development between the age of 4-21 years using quantitative four-dimensional maps and time-lapse sequences reveals that higher-order association cortices mature only after lower-order somatosensory and visual cortices are developed.