Imaging gene expression in human mesenchymal stem cells: from small to large animals.

@article{Willmann2009ImagingGE,
  title={Imaging gene expression in human mesenchymal stem cells: from small to large animals.},
  author={Juergen K Willmann and Ramasamy Paulmurugan and Martin Rodriguez-Porcel and William Stein and Todd J. Brinton and Andrew J. Connolly and Carsten Haagen Nielsen and Amelie M. Lutz and Jennifer Lyons and Fumiaki Ikeno and Yoriyasu Suzuki and Jarrett Rosenberg and Ian Yen-Hung Chen and Joseph C Wu and Alan Yeung and Paul G. Yock and Robert Clayton Robbins and Sanjiv Sam Gambhir},
  journal={Radiology},
  year={2009},
  volume={252 1},
  pages={117-27}
}
PURPOSE To evaluate the feasibility of reporter gene imaging in implanted human mesenchymal stem cells (MSCs) in porcine myocardium by using clinical positron emission tomography (PET)-computed tomography (CT) scanning. MATERIALS AND METHODS Animal protocols were approved by the Institutional Administrative Panel on Laboratory Animal Care. Transduction of human MSCs by using different doses of adenovirus that contained a cytomegalovirus (CMV) promoter driving the mutant herpes simplex virus… CONTINUE READING