Imaging feedback of tissue liquefaction (histotripsy) in ultrasound surgery

High intensity pulsed ultrasound was used to disrupt liver tissue through cavitation while monitoring with 8 MHz ultrasound imaging. Application of 2000 pulses (sufficient to liquefy the target tissue) resulted in an average 22.4 dB reduction in speckle amplitude. This method may provide effective feedback in ultrasound surgery using cavitation.