Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with 18F-FAHA

@article{Yeh2013ImagingER,
  title={Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with 18F-FAHA},
  author={Hsien-Hsien Yeh and M. Tian and R. Hinz and Daniel Young and A. Shavrin and Uday Mukhapadhyay and L. Flores and J. Balatoni and S. Soghomonyan and H. Jeong and A. Pal and R. Uthamanthil and James Jackson and R. Nishii and H. Mizuma and H. Onoe and S. Kagawa and T. Higashi and N. Fukumitsu and M. Alauddin and W. Tong and K. Herholz and J. Gelovani},
  journal={NeuroImage},
  year={2013},
  volume={64},
  pages={630-639}
}
Epigenetic modifications mediated by histone deacetylases (HDACs) play important roles in the mechanisms of different neurologic diseases and HDAC inhibitors (HDACIs) have shown promise in therapy. However, pharmacodynamic profiles of many HDACIs in the brain remain largely unknown due to the lack of validated methods for noninvasive imaging of HDAC expression-activity. In this study, dynamic PET/CT imaging was performed in 4 rhesus macaques using [(18)F]FAHA, a novel HDAC substrate, and [(18)F… Expand
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