Imaging early steps of human T cell activation by antigen-presenting cells.

@article{Donnadieu1992ImagingES,
  title={Imaging early steps of human T cell activation by antigen-presenting cells.},
  author={Emmanuel Donnadieu and D C{\'e}fai and Yusuf P. Tan and G Paresys and Georges Bismuth and Alain Trautmann},
  journal={Journal of immunology},
  year={1992},
  volume={148 9},
  pages={2643-53}
}
In this work the Ca2+ response and the morphological changes elicited by Ag in human CD4+ T cells are described at the single cell level. The APC used to present the diphtheria toxoid Ag to a human diphtheria toxoid-specific T cell clone were murine L cell fibroblast transfectants expressing MHC class II molecules. The increase of the intracellular Ca2+ concentration, [Ca2+]i, which is one of the earliest steps of the response to TCR stimulation, was followed by fluorimetry with fura-2 on an… CONTINUE READING
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