Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin.

@article{Farr2014ImagingEE,
  title={Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin.},
  author={Tracy D. Farr and Chian-Hui Lai and Dan Gr{\"u}nstein and Guillermo Orts-Gil and Cheng-Chung Wang and Philipp Boehm-Sturm and Peter H Seeberger and Christoph Harms},
  journal={Nano letters},
  year={2014},
  volume={14 4},
  pages={2130-4}
}
Activation of the endothelium is a pivotal first step for leukocyte migration into the diseased brain. Consequently, imaging this activation process is highly desirable. We synthesized carbohydrate-functionalized magnetic nanoparticles that bind specifically to the endothelial transmembrane inflammatory proteins E and P selectin. Magnetic resonance imaging revealed that the targeted nanoparticles accumulated in the brain vasculature following acute administration into a clinically relevant… CONTINUE READING

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