Imaging calcium entering the cytosol through a single opening of plasma membrane ion channels: SCCaFTs--fundamental calcium events.

@article{Zou2004ImagingCE,
  title={Imaging calcium entering the cytosol through a single opening of plasma membrane ion channels: SCCaFTs--fundamental calcium events.},
  author={Hui Wen Zou and Lawrence M. Lifshitz and Richard A. Tuft and Kevin E. Fogarty and Joshua A. Singer},
  journal={Cell calcium},
  year={2004},
  volume={35 6},
  pages={523-33}
}
Recently, it has become possible to record the localized fluorescence transient associated with the opening of a single plasma membrane Ca(2+) permeable ion channel using Ca(2+) indicators like fluo-3. These Single Channel Ca(2+) Fluorescence Transients (SCCaFTs) share some of the characteristics of such elementary events as Ca(2+) sparks and Ca(2+) puffs caused by Ca(2+) release from intracellular stores (due to the opening of ryanodine receptors and IP(3) receptors, respectively). In contrast… CONTINUE READING