Imaging axonal damage of normal-appearing white matter in multiple sclerosis.

  title={Imaging axonal damage of normal-appearing white matter in multiple sclerosis.},
  author={Lin Fu and Paul M. Matthews and Nicola de Stefano and Keith J. Worsley and Sridar Narayanan and Gordon S. Francis and Jack P. Antel and Christina Wolfson and Douglas L. Arnold},
  journal={Brain : a journal of neurology},
  volume={121 ( Pt 1)},
The current study was designed to determine the relative distribution of decreases of N-acetylasparate (NAA), a marker of axonal damage, between lesions and normal-appearing white matter of patients with established multiple sclerosis and to test for associations between changes in the ratio of NAA to creatine/phosphocreatine (NAA:Cr) in those compartments and changes in disability. Data were collected from a 30-month longitudinal study of 28 patients with either a relapsing course with partial… 

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